Wholesale Price Brain Health Supplements Nootropics Pharmaceutical Chemical Peptide Isrib (trans-isoMer) raw Powder CAS 1597403-47-8 Isrib Transisomer

Short Description:

Name:	Slu-PP-332
CAS:	303760-60-3
Purity:	99%+
MOQ:	1g-1kg
Shelf life:	Two Years

FOB Price: : US $0.1 - 1,000 / grams

Min.Order Quantity:: 1-100 grams

Send email to us

Product Detail

Product Tags

ISRIB (trans-isomer), the trans isomer of ISRIB, is a highly selective PERK inhibitor with an IC50 of 5 nM.

Product Name	ISRIB (trans-isomer)
CAS	1597403-47-8
Appearance	White powder
MF	C22H24Cl2N2O4
Molecular Weight	451.34
Purity	99%
Storage	Keep in a cool, dry, dark location in a tightly sealed container or cylinder
Shelf Life	24 Months

Product Description:

ISRIB has good pharmacokinetic characteristics and good bioavailability in vivo. Intraperitoneal injection (0.25 mg/kg) of ISRIB in mice increases long-term memory by enhancing spatial memory and fear memory.

ISRIB (trans-isomer) is a highly selective inhibitor of PERK (PKR-like endoplasmic reticulum kinase), with an IC50 of 5 nM. It is a promising compound for research into cellular stress responses, memory enhancement, and therapeutic applications targeting unfolded protein response (UPR) pathways.

Biological Activity:

Mechanism:
- ISRIB inhibits PERK signaling by suppressing eIF2α phosphorylation and its downstream effects, including ATF4 expression, without significantly affecting XBP1s mRNA splicing or XBP1s protein expression.
- It targets the Integrated Stress Response (ISR) by modulating translation and stress granule assembly.
Key Metrics:
- Target: PERK (IC50 = 5 nM in a cell-free assay).

In Vitro Studies:

ISRIB effectively inhibits endogenous ATF4 expression, reducing cellular survival rates under endoplasmic reticulum (ER) stress.
Maintains XBP1s mRNA and protein levels, indicating selective inhibition of the PERK pathway.

In Vivo Studies:

ISRIB exhibits favorable pharmacokinetic properties and good bioavailability in vivo.
Animal Model: Mice injected intraperitoneally (0.25 mg/kg).
Results:
- Enhances spatial and fear memory, improving long-term memory formation.
- Demonstrates potential in modulating cognitive functions and stress response pathways.

Applications:

Neuroscience Research: Enhances memory and studies cellular responses to ER stress.
Molecular Biology: Investigates the Integrated Stress Response (ISR) and unfolded protein response (UPR).
Drug Development: Serves as a tool for developing PERK-related therapeutics.

Features:

High Selectivity: Specifically inhibits PERK with minimal off-target effects.
Versatile Research Uses: Applicable in memory studies, stress pathway modulation, and therapeutic development.
Potent Activity: Demonstrates efficacy at nanomolar concentrations.

Storage Information:

Conditions: Store at 2-8°C in a sealed container. Protect from moisture and air to maintain product stability.

Safety and Handling:

This product is intended for research purposes only. Not for human or veterinary use.

For further inquiries regarding this product, including packaging and bulk availability, please contact us.

Purity	99%+	Custom content	2mg 5mg 10mg 15mg 20mg 30me etc.
Actual peptide content	Exceed the standard	Payment method	Bank Transfer BTC USDT Paypal
Cleanliness	Sterile	Transportation time	7-15days
Test Report	COA HPLC Third party testing	Disguise	Can provide
Customized top color	Red Yellow Blue Black Purple White Green	Resend policy	According to different countries

Retatrutide Peptide Mazdutide Sem Tirz Cagrilintide MT-2 DSIP Semax Selank GHK-CU Epithalon Tirz 5mg 10mg 15mg Survodutide:Retatrutide is a glucose-dependent insulinotropic polypeptide (GIP)/glucagon-like peptide 1 (GLP-1)/glucagon (GCG) triple receptor agonist. The safety and effectiveness of GLP-1 targeted therapy after its release on the market has led to research on incretin therapy targeting multiple mechanisms. Because the regulation of energy metabolism itself involves multiple hormones, drugs targeting multiple signaling pathways may have synergistic effects, thus Make the therapeutic effect more significant.

A variety of shipping methods for you to choose

Transportation Time	Shipping method	Cargo weight requirements	Advantage
3-7 days	DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS	Suitable for under 50kg. International door to door express	We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places.
7-15 days	By Air	Suitable for more than 50kg. fast and cheaper for large order
15-60 days	By Sea	Suitable for more than 500kg. Cheapest shipping way

A variety of payment methods for you to choose

Payment Terms	Company Bank transfer(European accounts, American accounts)
	Credit Card(VISA/Master)
	Western Union
	MoneyGram
	Paypal
	Alipay
	WeChat pay

Our Promise To You:

Every product we sell is 100% Authentic & Top Quality.

Your Satisfaction is 100% Guaranteed or your money back.

Packing

· 1kg/aluminium foil bag, with two plastic bags inside.
· 25kg/fiber drum, with two plastic bags inside.
Size:ID 42cm*H52cm,0.08m3/drum;
Net Weight:25kgs Gross Weight:28kgs.

Our Advantages

1. Pharmaceutical Expertise: - With years of experience in the pharmaceutical industry, our team brings extensive expertise in product development, manufacturing, and distribution.

2. High-Quality Products: - We adhere to stringent quality control standards and Good Manufacturing Practices (GMP) to ensure the safety and efficacy of our pharmaceutical products.

3. Diverse Product Range: - Our extensive product portfolio includes Active Pharmaceutical Ingredients (APIs), finished dosage forms, pharmaceutical intermediates, and customized

pharmaceutical solutions to meet a wide range of needs.

4. Customization Capabilities: - We offer tailored solutions for pharmaceutical product development and manufacturing to meet the unique requirements of our clients.

5. Global Reach:- -We have a strong international presence, allowing us to serve customers and partners worldwide. Our products are distributed in various regions, ensuring accessibility and reliability.

6. Regulatory Compliance:- -We maintain strict adherence to international regulatory standards and guidelines, ensuring that our products meet all necessary regulatory requirements.

7. Responsive Customer Support: - Our dedicated customer support team is available to assist you promptly with inquiries, orders, and technical support.

8. Competitive Pricing: - We strive to provide competitive pricing for our high-quality pharmaceutical products, enabling cost-effective solutions for our clients.

9. Sustainable Practices: - We are committed to environmentally responsible practices in our manufacturing processes and operations, contributing to a sustainable future.

10. Innovation and Research: - We invest in research and development to stay at the forefront of pharmaceutical advancements and deliver innovative products to our customers.

11. Long-Term Partnerships: - We value long-term relationships with our customers and partners, fostering trust and collaboration for mutual success.

12. Transparent Communication: - We believe in transparent and open communication, ensuring that our clients are informed and confident in their dealings with us.